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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KCNH2
All Species:
11.52
Human Site:
T145
Identified Species:
31.67
UniProt:
Q12809
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12809
NP_000229.1
1159
126655
T145
V
G
S
P
A
H
D
T
N
H
R
G
P
P
T
Chimpanzee
Pan troglodytes
XP_001137384
1094
119779
V114
L
C
L
L
G
I
A
V
V
R
G
R
D
G
S
Rhesus Macaque
Macaca mulatta
XP_001097904
1195
134865
T139
V
T
D
E
N
A
A
T
P
E
R
V
N
P
I
Dog
Lupus familis
XP_535934
1197
134439
S140
T
D
E
E
N
A
A
S
P
E
R
V
N
P
I
Cat
Felis silvestris
Mouse
Mus musculus
O35219
1162
126867
T145
V
G
S
P
A
H
D
T
N
H
R
G
P
S
T
Rat
Rattus norvegicus
O08962
1163
126933
T145
V
G
S
P
A
H
D
T
N
H
R
G
P
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511873
1200
135504
S140
T
D
E
E
N
A
D
S
P
E
R
L
N
S
L
Chicken
Gallus gallus
Q9PT84
526
59775
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001036187
1253
139909
D146
L
D
S
S
P
G
R
D
I
N
N
K
N
P
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91
55.9
56.6
N.A.
95.9
95.5
N.A.
59
38.2
N.A.
59.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
91.8
68.1
68.3
N.A.
96.9
96.7
N.A.
70.4
41.6
N.A.
69.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
26.6
13.3
N.A.
93.3
93.3
N.A.
13.3
0
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
26.6
20
N.A.
93.3
93.3
N.A.
20
0
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
34
34
34
0
0
0
0
0
0
0
0
% A
% Cys:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
34
12
0
0
0
45
12
0
0
0
0
12
0
0
% D
% Glu:
0
0
23
34
0
0
0
0
0
34
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
34
0
0
12
12
0
0
0
0
12
34
0
12
0
% G
% His:
0
0
0
0
0
34
0
0
0
34
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
12
0
0
0
0
0
34
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% K
% Leu:
23
0
12
12
0
0
0
0
0
0
0
12
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
34
0
0
0
34
12
12
0
45
0
0
% N
% Pro:
0
0
0
34
12
0
0
0
34
0
0
0
34
45
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
12
0
0
12
67
12
0
0
0
% R
% Ser:
0
0
45
12
0
0
0
23
0
0
0
0
0
34
12
% S
% Thr:
23
12
0
0
0
0
0
45
0
0
0
0
0
0
34
% T
% Val:
45
0
0
0
0
0
0
12
12
0
0
23
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _